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Pathways Recommended:	Neuronal Signaling JAK/STAT Signaling

Results for "

Nrf2 signaling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Amyloid-β (1) Apoptosis (8) Autophagy (1) Bacterial (1) Bcl-2 Family (3) Caspase (3) COX (1) DNA/RNA Synthesis (1) EGFR (1) Endogenous Metabolite (2) Fungal (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Influenza Virus (1) Interleukin Related (1) Keap1-Nrf2 (21) MMP (1) mTOR (3) NF-κB (8) NO Synthase (1) p38 MAPK (2) PARP (1) Phosphatase (1) PI3K (3) Reactive Oxygen Species (6) Sirtuin (1) STAT (1) STING (1) TNF Receptor (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (18) Metabolic Disease (2) Neurological Disease (5)

By Targets:

Akt (3)

Amyloid-β (1)

Apoptosis (8)

Autophagy (1)

Bacterial (1)

Bcl-2 Family (3)

Caspase (3)

COX (1)

DNA/RNA Synthesis (1)

EGFR (1)

Endogenous Metabolite (2)

Fungal (1)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (1)

Influenza Virus (1)

Interleukin Related (1)

Keap1-Nrf2 (21)

MMP (1)

mTOR (3)

NF-κB (8)

NO Synthase (1)

p38 MAPK (2)

PARP (1)

Phosphatase (1)

PI3K (3)

Reactive Oxygen Species (6)

Sirtuin (1)

STAT (1)

STING (1)

TNF Receptor (1)

By Research Areas:

Cancer (10)

Cardiovascular Disease (1)

Infection (2)

Inflammation/Immunology (18)

Metabolic Disease (2)

Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Targets Recommended: RGS Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134001

CBR-470-2

Keap1-Nrf2 Metabolic Disease

CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis .

CBR-470-2	Keap1-Nrf2	Metabolic Disease
CBR-470-2, a glycine-substituted analog, can activate *NRF2* signaling. CBR-470-2 can be used for the research of modulation glycolysis .

HY-110275

RA839	Keap1-Nrf2	Others
RA839 is a noncovalent small molecule binder to Keap1 with a K_d of ∼6 μM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2 .

HY-131592

Tricetin	Apoptosis Keap1-Nrf2	Neurological Disease Inflammation/Immunology Cancer
Tricetin is a potent competitive inhibitor of the *Keap1-Nrf2* Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway .

HY-149244

Nrf2 activator-7

Keap1-Nrf2 Others

Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway.

Nrf2 activator-7	Keap1-Nrf2	Others
Nrf2 activator-7 (Compound 12b) is a potent *Nrf2* activator and significantly activates the *Nrf2* signaling pathway.

HY-N1244

Sarmentosin Sarmentosine; Sarmentosine (glycoside)	Keap1-Nrf2 mTOR Apoptosis	Cancer
Sarmentosin is an activator of *Nrf2. Sarmentosin inhibits mTOR* signaling and induces autophagy-dependent apoptosis in human HCC cells .

HY-N3260

Methyllucidone	Reactive Oxygen Species Keap1-Nrf2 PI3K	Inflammation/Immunology
Methyllucidone is a neuroprotective agent and an antioxidant that can be isolated from Lindera erythrocarpa Makino. Methyllucidone inhibits the ROS production, and activates antioxidant signaling pathways that include *Nrf-2* and PI3K .

HY-N2292

Kinsenoside 1 Publications Verification	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).

HY-12212

Omaveloxolone 15+ Cited Publications RTA 408	Keap1-Nrf2 STING Apoptosis	Inflammation/Immunology Cancer
Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates *Nrf2* and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.

HY-13755

Sulforaphane Maximum Cited Publications 33 Publications Verification	HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species	Inflammation/Immunology Cancer
Sulforaphane is an orally active inducer of the *Keap1/Nrf2/ARE* pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties .

HY-N0637

Eriodictyol 3 Publications Verification Huazhongilexone	Keap1-Nrf2 Influenza Virus DNA/RNA Synthesis Endogenous Metabolite	Infection Inflammation/Immunology
Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces *Nrf2* signaling pathway. Eriodictyol is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 18 nM.

HY-153340

I-152	Keap1-Nrf2	Metabolic Disease
I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates *NRF2* and ATF4 signals. I-152 has anti-proliferative properties .

HY-N11657

Sanggenon A Sanggenone A	NF-κB Keap1-Nrf2	Inflammation/Immunology
Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide .

HY-13755A

(R)-Sulforaphane L-Sulforaphane	Keap1-Nrf2 Bcl-2 Family Caspase Reactive Oxygen Species NF-κB	Inflammation/Immunology Cancer
(R)-Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R)-Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R)-Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including *Nrf2, NF-κB, and AP-1*. (R)-Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses .

HY-162170

Anti-inflammatory agent 72	NF-κB Keap1-Nrf2 p38 MAPK	Inflammation/Immunology
Anti-inflammatory agent 72 (compound 5) is a novel resveratrol derivative hybrid with benzoylhydrazine. Anti-inflammatory agent 72 shows anti-inflammatory and antioxidant activities by activating *Nrf2* and inhibiting NF-κB p65/iNOS and MAPKs signaling pathways .

HY-N8263

Nepetoidin B	Bacterial Fungal NF-κB	Infection Inflammation/Immunology
Nepetoidin B, an anti-inflammatory agent, inhibits inflammation by modulating the NF-κB and *Nrf2/HO-1* signaling pathways. Nepetoidin B also has antifungal and antibacterial activity. Nepetoidin B is a natural product that can be obtained from Salvia plebeia R. Br. Nepetoidin B can be used in anti-inflammatory and anti-infectious research .

HY-126390

(E/Z)-BCI NSC 150117	Phosphatase Apoptosis	Inflammation/Immunology Cancer
(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway .

HY-19893

Antroquinonol (+)-Antroquinonol
Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects . Antroquinonol can be used for the research of colon cancer . Antroquinonol reduces oxidative stress by enhancing the *Nrf2* signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice .

HY-N1970

5,7-Dihydroxychromone 1 Publications Verification
5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates *Nrf2/ARE* signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells .

HY-149351

NF-κB-IN-10	NF-κB	Cardiovascular Disease
NF-κB-IN-10 (compound E1) is an NF-κB inhibitor that can improve heart failure by reducing oxidative stress and inflammation by regulating *Nrf2/NF-κB* signaling pathway. NF-κB-IN-10 inhibits LPS-induced NO production and expression of iNOS and COX-2 in RAW264.7 cells. NF-κB-IN-10 can be used in the research of cardiovascular diseases .

HY-N1967

Dihydrocurcumin
Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways .

HY-N0028

Forsythiaside A 1 Publications Verification	Others	Inflammation/Immunology
Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ_25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice .

HY-N1445

Isoquercetin 1 Publications Verification Quercetin 3-glucoside
Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway . Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies .

HY-125136

Chaetominine (-)-Chaetominine	PI3K Akt Keap1-Nrf2	Cancer
Chaetominine is an alkaloidal metabolite. Chaetominine has cytotoxicity against human leukemia K562 and colon cancer SW1116 cell lines. Chaetominine reduces MRP1-mediated agent resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells .

HY-145532

S-Allylmercaptocysteine	Apoptosis NF-κB Keap1-Nrf2	Inflammation/Immunology Cancer
S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases. S-allylmercaptocysteine achieves its anti-cancer effect through a variety of pathways such as inducing the apoptosis of cancer cells through the TGF-β signaling pathway, or reducing the NF-κB activity and up-regulating Nrf2 to achieve the effects of anti-inflammation and anti-oxidation .

HY-N6953

Garcinone D 2 Publications Verification	STAT Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease
Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of *phosphorylated signal* transducer and activator of transcription 3 (p-STAT3)*, Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1)* in concentration- and time- dependent manners .

HY-163151

JE-133	PI3K Akt p38 MAPK	Neurological Disease Inflammation/Immunology
JE-133 is an optically active isochromane-2H-chromene conjugate. JE-133 exhibits antioxidant and anti-inflammatory activities. JE-133 is a neuroprotective agent that effectively inhibits neuronal oxidative damage associated with PI3K/Akt and MAPK signaling pathways. JE-133 can also inhibit lipopolysaccharide (LPS) (HY-D1056)-induced neuroinflammation by regulating JAK/STAT and *Nrf2* signaling pathways .

HY-N1326

Santamarine Santamarin; Balchanin	Keap1-Nrf2	Inflammation/Immunology
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities .

HY-155784

SPC-180002	Sirtuin Reactive Oxygen Species Keap1-Nrf2	Cancer
SPC-180002 is a SIRT1/3 dual inhibitor, with IC₅₀ values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway .

HY-W016412

Coenzyme Q0 2 Publications Verification CoQ0	Apoptosis Autophagy EGFR Akt mTOR Caspase Bcl-2 Family Reactive Oxygen Species PARP COX NO Synthase TNF Receptor Interleukin Related MMP NF-κB	Neurological Disease Inflammation/Immunology Cancer
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

HY-N0787

Cryptochlorogenic acid 1 Publications Verification 4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid	Endogenous Metabolite NF-κB Keap1-Nrf2 mTOR HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
Cryptochlorogenic acid (4-Caffeoylquinic acid) is a naturally occurring phenolic acid compound with oral effectiveness, anti-inflammatory, antioxidant and anti-cardiac hypertrophy effects. Alleviating LPS (HY-D1056) and ISO (HY-B0468) by regulating proinflammatory factor expression, inhibiting NF-κB activity, promoting *Nrf2* nuclear transfer, and regulating PI3Kα/Akt/ mTOR / HIF-1α signaling pathway Induced physiological stress response .

HY-149246

Aβ-IN-6	Amyloid-β Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research .

NF-κB Signaling Compound Library	805 compounds
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. MCE owns a unique collection of 805 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Coenzyme Q0 2 Publications Verification CoQ0	Biochemical Assay Reagents
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

Tricetin	Flavonols Flavonoids Cupressaceae Classification of Application Fields Neurological Disease Thuja occidentalisLinn. Source classification Plants Disease Research Fields Inflammation/Immunology	Apoptosis Keap1-Nrf2
Tricetin is a potent competitive inhibitor of the *Keap1-Nrf2* Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway .

Methyllucidone	Structural Classification Natural Products Source classification Plants Lauraceae	Reactive Oxygen Species Keap1-Nrf2 PI3K
Methyllucidone is a neuroprotective agent and an antioxidant that can be isolated from Lindera erythrocarpa Makino. Methyllucidone inhibits the ROS production, and activates antioxidant signaling pathways that include *Nrf-2* and PI3K .

Kinsenoside 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Orchidaceae Plants Anoectochilus Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Apoptosis
Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).

Sulforaphane Maximum Cited Publications 33 Publications Verification	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species
Sulforaphane is an orally active inducer of the *Keap1/Nrf2/ARE* pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties .

Sarmentosin Sarmentosine; Sarmentosine (glycoside)	Structural Classification Natural Products Animals Source classification Saccharides Monosaccharides	Keap1-Nrf2 mTOR Apoptosis
Sarmentosin is an activator of *Nrf2. Sarmentosin inhibits mTOR* signaling and induces autophagy-dependent apoptosis in human HCC cells .

Eriodictyol 3 Publications Verification Huazhongilexone	Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids other families Microorganisms Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Influenza Virus DNA/RNA Synthesis Endogenous Metabolite
Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces *Nrf2* signaling pathway. Eriodictyol is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 18 nM.

Sanggenon A Sanggenone A	Structural Classification Flavonoids Source classification Morus alba L. Plants Moraceae Other Flavonoids	NF-κB Keap1-Nrf2
Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide .

(R)-Sulforaphane L-Sulforaphane	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Keap1-Nrf2 Bcl-2 Family Caspase Reactive Oxygen Species NF-κB
(R)-Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R)-Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R)-Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including *Nrf2, NF-κB, and AP-1*. (R)-Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses .

Nepetoidin B	Structural Classification Labiatae Source classification Artemisia austriaca Jacq. Phenols Polyphenols Plants	Bacterial Fungal NF-κB
Nepetoidin B, an anti-inflammatory agent, inhibits inflammation by modulating the NF-κB and *Nrf2/HO-1* signaling pathways. Nepetoidin B also has antifungal and antibacterial activity. Nepetoidin B is a natural product that can be obtained from Salvia plebeia R. Br. Nepetoidin B can be used in anti-inflammatory and anti-infectious research .

Forsythiaside A 1 Publications Verification	Structural Classification Classification of Application Fields Oleaceae Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Inflammation/Immunology Disease Research Fields	Others
Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ_25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice .

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